[The study of the behavioral reactions and duration of ultrasonic vocalization in rats from females stressed during pregnancy].

Q3 Medicine

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI:10.17116/jnevro2025125031117

E A Muzyko, A S Lukina, D A Karelina, A S Tarasov, V N Perfilova, E M Frolov, M Yu Frolov

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引用次数: 0

Abstract

Objective: To study the psycho-emotional state and its relationship to the duration of ultrasonic vocalization in the offspring of rats with physiological and stress-complicated pregnancy.

Material and methods: The experiments were performed on the offspring (n=120) of rats with physiological pregnancy and the offspring of animals stressed during the entire gestation period (21-23 days). Study animals were divided into the following groups: 1 - intact - males and females (n=52) born to healthy rats; 2 - stress - males and females (n=68) born to rats that underwent stress during pregnancy.

At the age of 17 days, the total vocalization duration (at 50 kHz) was recorded in rats. To assess the psycho-emotional state of the offspring, the open field and elevated plus maze tests were performed at 22 days, marble burying at 35 days, and Porsolt forced swimming test at 47 days. To assess cognitive function in the offspring, short-term working memory was examined in the recognition of a new object test at 35 days and long-term memory in the conditioned passive avoidance reflex test at the age of 47 days.

Results: The results of the open field and elevated plus maze tests indicated that the offspring of females stressed during pregnancy showed anxious behavior. In addition, animals from stressed rats exhibited compulsive and depressive behaviors in the marble burying and Porsolt forced swimming tests. The offspring of stressed rats showed impaired reproduction of the memory traces in the conditioned passive avoidance reflex test.

Conclusion: In the offspring of females stressed during pregnancy, anxious, compulsive, and depressive behavior is observed, accompanied by an increase in the duration of ultrasonic vocalization at 50 kHz.

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[研究妊娠期受压雌性大鼠的行为反应和超声波发声持续时间]。

目的研究生理性妊娠和应激性妊娠大鼠后代的心理情绪状态及其与超声波发声持续时间的关系：实验对象为生理性妊娠大鼠的后代（n=120）和整个妊娠期（21-23 天）内受到应激的动物的后代。研究动物分为以下几组：1-完整组--健康大鼠所生的雄性和雌性（n=52）；2--应激组--妊娠期应激大鼠所生的雄性和雌性（n=68）。为了评估后代的心理情绪状态，在大鼠出生后 22 天进行了开阔地和高架加迷宫试验，在出生后 35 天进行了大理石埋藏试验，在出生后 47 天进行了 Porsolt 强迫游泳试验。为了评估后代的认知功能，在35天时进行了识别新物体测试，以检查短期工作记忆；在47天时进行了条件性被动回避反射测试，以检查长期记忆：结果：开阔地和高架加迷宫试验的结果表明，妊娠期受压雌性大鼠的后代表现出焦虑行为。此外，应激大鼠的动物在大理石埋藏和波尔索尔特强迫游泳试验中表现出强迫和抑郁行为。应激大鼠的后代在条件性被动回避反射试验中表现出记忆痕迹再现能力受损：结论：妊娠期受惊吓的雌性大鼠的后代会出现焦虑、强迫和抑郁行为，同时50千赫超声波发声的持续时间会延长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova 医学-精神病学

CiteScore

1.10

自引率

0.00%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова. Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.