The global prevalence of anemia in patients with anorexia nervosa: a systematic review and meta-analysis.

IF 2.7 3区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY

BMC Psychology Pub Date : 2025-04-07 DOI:10.1186/s40359-025-02647-7

Nader Salari, Sadaf Razavizadeh, Amir Abdolmaleki, Pegah Heidarian, Avijeh Rahimi, Shamarina Shohaimi, Masoud Mohammadi

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Abstract

Background: Anorexia nervosa (AN) is a mental disorder characterized by severe loss of appetite and low nutrient intake. Along with many complications, the anorexia nervosa eventually disrupts hematogenesis and the occurrence of anemia. Thus, the present study aimed to investigate the global prevalence of anemia in anorexia nervosa patient.

Methods: Systematic searching was applied (by August 10, 2024) in databases of PubMed, Scopus, WoS, ScienceDirect, Embase, and the Google Scholar search engine. Selected investigations were imported to the EndNote Citation Management Software and duplicate papers were merged. Following consideration of inclusion and exclusion criteria (during primary and secondary screening) relevant papers were selected and underwent validation. Finally, eligible papers were selected for data extraction and meta-analysis (CMA v.2). The I2 index was used for heterogeneity assessment, and the Random Effect Model was used for meta-analysis. The results were categorized based on hematocrit and hemoglobin levels, and study type, and meta-regression was also applied for sample size and year of paper publication.

Results: In the review of 9 eligible studies, the global prevalence of anemia in anorexia nervosa patient was found to be 44.8% (95%CI:25.7-65.7). Also, this value was detected in 48% (95%CI:19.9-77.4) and 43.4% (95%CI:18.6-72) based on hematocrit and hemoglobin levels, respectively. Meta-regression analysis showed that following the increase in sample size and year of paper publication, the global prevalence of anemia in Anorexia nervosa patient decreased and increased, respectively.

Conclusion: A relatively high prevalence of anemia in individuals with anorexia nervosa requires proper attention to the regular blood monitoring and laboratory evaluations of the patients.

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神经性厌食症患者贫血的全球患病率：系统回顾和荟萃分析。

背景：神经性厌食症（Anorexia nervosa， AN）是一种以食欲严重丧失和营养摄入低为特征的精神障碍。神经性厌食症伴随许多并发症，最终破坏血液生成和贫血的发生。因此，本研究旨在调查神经性厌食症患者贫血的全球患病率。方法：系统检索PubMed、Scopus、WoS、ScienceDirect、Embase、谷歌Scholar等数据库（截止到2024年8月10日）。将选定的调查输入到EndNote引文管理软件中，并合并重复的论文。在考虑纳入和排除标准（在初级和二级筛选期间）后，选择相关论文并进行验证。最后，选择符合条件的论文进行数据提取和meta分析（CMA v.2）。异质性评价采用I2指数，meta分析采用随机效应模型。结果根据红细胞压积和血红蛋白水平、研究类型进行分类，并对样本量和论文发表年份进行meta回归。结果：在9项符合条件的研究中，神经性厌食症患者贫血的全球患病率为44.8% （95%CI:25.7-65.7）。此外，基于红细胞压积和血红蛋白水平，该值分别为48% （95%CI:19.9-77.4）和43.4% （95%CI:18.6-72）。meta回归分析显示，随着样本量的增加和论文发表年份的增加，神经性厌食症患者贫血的全球患病率分别下降和上升。结论：神经性厌食症患者贫血发生率较高，应重视定期血液监测和实验室检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychology Psychology-Psychology (all)

CiteScore

3.90

自引率

2.80%

发文量

265

审稿时长

24 weeks

期刊介绍： BMC Psychology is an open access, peer-reviewed journal that considers manuscripts on all aspects of psychology, human behavior and the mind, including developmental, clinical, cognitive, experimental, health and social psychology, as well as personality and individual differences. The journal welcomes quantitative and qualitative research methods, including animal studies.