Does the lateral hypothalamus govern the transition between appetitive and consummatory feeding?

Abstract

Feeding is a cyclic behaviour that includes appetitive, consummatory and termination phases. Identifying the neural circuits controlling these phases and triggering specific transitions between phases would be a key advance in understanding feeding behaviour. The lateral hypothalamus (LH) has long been recognized for its central role in feeding. We review evidence suggesting that the LH acts as a regulator of the appetitive-consummatory transition using a switchboard-like circuit architecture. Within the LH, several neuronal subpopulations can be defined based on molecular markers, and - although these subpopulations are functionally diverse - they contribute to appetitive and consummatory behaviours to varying extents. We summarise the current evidence on whether these subpopulations have functional identities and speculate on the role of the LH as a controller of behavioural transitions.