Small Intestinal Bacterial Overgrowth in a Healthy Female Patient Caused by Long-term Oral Proton Pump Inhibitor Administration.

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-05 DOI:10.2169/internalmedicine.4376-24

Koichi Soga, Sotaro Yamada, Yuto Suzuki, Yumi Kusano, Ikuhiro Kobori, Yasumi Katayama, Masaya Tamano

引用次数: 0

Abstract

Small-intestinal bacterial overgrowth (SIBO) causes gastrointestinal symptoms. Proton pump inhibitors (PPIs) are commonly used for acid peptic diseases; however, their long-term use can alter the gut microbiota, resulting in adverse effects. We herein report the case of a 26-year-old Japanese woman with SIBO caused by prolonged PPI use. After switching to a H2 receptor antagonist, her symptoms and blood test results improved. This case highlights the need to understand the pathogenesis of SIBO and also the risks associated with prolonged PPI use.

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健康女性长期口服质子泵抑制剂致小肠细菌过度生长1例。

小肠细菌过度生长（SIBO）引起胃肠道症状。质子泵抑制剂（PPIs）通常用于酸性消化性疾病；然而，长期使用它们会改变肠道微生物群，导致不良反应。我们在此报告一例26岁的日本女性因长期使用PPI而导致SIBO。改用H2受体拮抗剂后，她的症状和血液检查结果有所改善。本病例强调需要了解SIBO的发病机制以及长期使用PPI的相关风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.