One pot synthesis and mechanistic insights of quinazoline and related molecules

Abstract

One-pot synthesis of quinazoline derivatives has emerged as a highly efficient and sustainable strategy for the preparation of these bioactive compounds. This review highlights the recent advancements in the one-pot synthetic routes to quinazoline and its derivatives. It emphasises on the development of efficient catalysts including transition metal, organo-catalyst, and environmental friendly reagents, which will significantly improve reaction selectivity and yields. Ultimately, this review provides an in-depth overview of the progress, mechanistic pathways, challenges, and future prospects of one-pot synthesis of quinazoline and related molecules, highlighting the potential of this approach to revolutionize synthetic organic chemistry.