Amirhossein Ahmadi, Zahra Nozhat, Amir Shadboorestan, Mohsen Cheki
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引用次数: 0
Abstract
Humans encounter ionizing radiation (IR) through various ways, such as medical applications, agricultural industry, and potential exposure from radioactive materials or acts of radiological terrorism. Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) are crucial for maintaining the balance of blood cell lineages. The hematopoietic system, recognized as the most sensitive human tissue, is severely affected by IR, which can result in bone marrow (BM) failure, increased susceptibility to infections, hemorrhagic events, or anemia in affected individuals. Therefore, it is essential to develop radioprotective compounds to protect HSCs/HPCs. This review highlights several radioprotective agents that protect the hematopoietic system from IR-related damage to HSCs and HPCs and provides an overview of the mechanisms involved in damage and protection.
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