Phenoxybiphenyl derivatives from an endophyte, Neohendersonia kickxii

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-03 DOI:10.1016/j.fitote.2025.106518

Reo Takahashi , Zulfikar , Mayuka Hakozaki , Yuko Kanno , Shota Uesugi , Takuya Koseki , Yoshihito Shiono

引用次数: 0

Abstract

Three undescribed phenoxybiphenyl, neohenbiphenylols A (1), B (2) and C (3) along with known of diphenyl ethers 4, and 5, and dibenzofuran 6 were isolated from the endophyte Neohendersonia kickxii RT-749. The structures of these undescribed compounds, including their absolute configurations, were elucidated by analyses of NMR, UV, IR, HRESITOFMS, and ECD data. Compounds 1–3 showed cytotoxicity against human promyelocytic leukemia (HL60) cells with IC₅₀ values of 3.7, 4.3 and 7.3 μM, respectively, and antimicrobial activity against Bacillus subtilis with an MIC value of 25 μgmL^-1.

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内生菌新亨德菌的苯氧联苯衍生物。

从内生菌新亨dersonia kickxii RT-749中分离到3个未描述的苯氧联苯、新亨联苯酚A(1)、B(2)和C(3)，以及已知的二苯醚4、5和二苯并呋喃6。通过NMR、UV、IR、HRESITOFMS和ECD数据分析，确定了化合物的结构和绝对构型。化合物1 ~ 3对人早幼粒细胞白血病（HL60）细胞的IC50值分别为3.7、4.3和7.3 μM，对枯草芽孢杆菌的抑菌活性为25 μg/ml。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.