Roles of the gut microbiota in hepatocellular carcinoma: from the gut dysbiosis to the intratumoral microbiota.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-04-04 DOI:10.1038/s41420-025-02413-z

Yiqin Wang, Yongqiang Li, Yong Lin, Chuangyu Cao, Dongcheng Chen, Xianguang Huang, Canhua Li, Haoming Xu, Huasheng Lai, Huiting Chen, Yongjian Zhou

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引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) is closely linked to alterations in the gut microbiota. This dysbiosis is characterized by significant changes in the microbial population, which correlate with the progression of HCC. Gut dysbiosis ultimately promotes HCC development in several ways: it damages the integrity of the gut-vascular barrier (GVB), alters the tumor microenvironment (TME), and even affects the intratumoral microbiota. Subsequently, intratumoral microbiota present a characteristic profile and play an essential role in HCC progression mainly by causing DNA damage, mediating tumor-related signaling pathways, altering the TME, promoting HCC metastasis, or through other mechanisms. Both gut microbiota and intratumoral microbiota have dual effects on HCC progression; a comprehensive understanding of their complex biological roles will provide a theoretical foundation for potential clinical applications in HCC treatment.

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肠道微生物群在肝细胞癌中的作用：从肠道生态失调到肿瘤内微生物群。

肝细胞癌（HCC）与肠道微生物群的改变密切相关。这种生态失调的特征是微生物种群的显著变化，这与HCC的进展有关。肠道生态失调最终以几种方式促进HCC的发展：它破坏肠血管屏障（GVB）的完整性，改变肿瘤微环境（TME），甚至影响肿瘤内微生物群。随后，肿瘤内微生物群呈现出特征特征，主要通过引起DNA损伤、介导肿瘤相关信号通路、改变TME、促进HCC转移或通过其他机制在HCC进展中发挥重要作用。肠道微生物群和肿瘤内微生物群对HCC的进展有双重影响；全面了解它们复杂的生物学作用将为HCC治疗的潜在临床应用提供理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.