Paraneoplastic immune manifestations of childhood Hodgkin's lymphoma.

Abstract

Autoimmune conditions like autoimmune haemolytic anaemia and autoimmune thrombocytopenic purpura as secondary manifestations of childhood Hodgkin's lymphoma (HL) have long been known. Although with a limited number of cases and limited knowledge of the pathogenesis behind, there is a lot left to be unveiled. Hence, in an effort to throw some light on this aspect, we present a series of three cases in their middle childhood, presenting with these autoimmune manifestations of autoimmune haemolytic anaemia and immune thrombocytopenia secondary to HL. The identification and knowledge of these conditions is of importance as they pose a certain challenge in the diagnosis as well as management.