Massive Malignant Transformation in a Patient with Hidradenitis Suppurativa during Anti-Tumor Necrosis Factor Treatment.

IF 1.7 4区医学 Q3 DERMATOLOGY

Advances in Skin & Wound Care Pub Date : 2025-06-01 Epub Date: 2025-04-04 DOI:10.1097/ASW.0000000000000303

Gabija Rudzikaitė, Jorinta Jokubaitė, Dominykas Markevičius, Justinas Pamedys, Tadas Raudonis

引用次数: 0

Abstract

Abstract: Hidradenitis suppurativa (HS) is a chronic skin condition that can lead to significant morbidity and, in some cases, transformation to squamous cell carcinoma (SCC). This report details the case of a 53-year-old man with a history of HS treatment with adalimumab and systemic antibiotics who developed well-differentiated SCC. For this malignant transformation, the patient required aggressive management, including radiation therapy, wide excision, and reconstructive surgery. Follow-up showed no disease progression. This case highlights the importance of early detection, routine screening, and a multidisciplinary approach in managing the risk of SCC in patients with HS.

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1例化脓性汗腺炎患者在抗肿瘤坏死因子治疗期间发生恶性转变。

摘要：化脓性汗腺炎（HS）是一种慢性皮肤病，可导致显著的发病率，在某些情况下，可转化为鳞状细胞癌（SCC）。本报告详细介绍了一名53岁男性的病例，他曾用阿达木单抗和全身抗生素治疗HS，后来发展为分化良好的SCC。对于这种恶性转变，患者需要积极的治疗，包括放射治疗、广泛切除和重建手术。随访未见疾病进展。该病例强调了早期发现、常规筛查和多学科方法在管理HS患者SCC风险中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Skin & Wound Care DERMATOLOGY-NURSING

CiteScore

2.50

自引率

12.50%

发文量

271

审稿时长

>12 weeks

期刊介绍： A peer-reviewed, multidisciplinary journal, Advances in Skin & Wound Care is highly regarded for its unique balance of cutting-edge original research and practical clinical management articles on wounds and other problems of skin integrity. Each issue features CME/CE for physicians and nurses, the first journal in the field to regularly offer continuing education for both disciplines.