Pavithra Nagarajan, Thomas W. Winkler, Amy R. Bentley, Clint L. Miller, Aldi T. Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R. Brown, John L. Morrison, Ayush Giri, Jeffrey R. O’Connell, Traci M. Bartz, Lisa de las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E. Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian’an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D. Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan van der Graaf, Peter J. van der Most, Yujie Wang, Stefan Weiss, Kenneth E. Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D. Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R. Attia, Lydia Bazzanno, Max A. Breyer, Jennifer A. Brody, Brian E. Cade, Hung-hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S. de Vries, Latchezar M. Dimitrov, Anh Do, Jiawen Du, Charles T. Dupont, Todd L. Edwards, Michele K. Evans, Tariq Faquih, Stephan B. Felix, Susan P. Fisher-Hoch, James S. Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G. Hairston, Anthony J. Hanley, Iris M. Heid, Sami Heikkinen, Heather M. Highland, Michelle M. Hood, Mika Kähönen, Carrie A. Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N. Kelly, Pirjo Komulainen, Daniel Levy, Henry J. Lin, Peter Y. Liu, Pedro Marques-Vidal, Joseph B. McCormick, Hao Mei, James B. Meigs, Cristina Menni, Kisung Nam, Ilja M. Nolte, Natasha L. Pacheco, Lauren E. Petty, Hannah G. Polikowsky, Michael A. Province, Bruce M. Psaty, Laura M. Raffield, Olli T. Raitakari, Stephen S. Rich, Renata L. Riha, Lorenz Risch, Martin Risch, Edward A. Ruiz-Narvaez, Rodney J. Scott, Colleen M. Sitlani, Jennifer A. Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems van Dijk, Otis D. Wilson, Rui Xia, Jie Yao, Kristin L. Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E. Below, Carsten A. Böger, David Conen, Simon R. Cox, Marcus Dörr, Mary F. Feitosa, Ervin R. Fox, Nora Franceschini, Sina A. Gharib, Vilmundur Gudnason, Sioban D. Harlow, Jiang He, Elizabeth G. Holliday, Zoltan Kutalik, Timo A. Lakka, Deborah A. Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C. Morrison, Brenda WJH Penninx, Patricia A. Peyser, Jerome I. Rotter, Harold Snieder, Tim D. Spector, Lynne E. Wagenknecht, Nicholas J. Wareham, Alan B. Zonderman, Kari E. North, Myriam Fornage, Adriana M. Hung, Alisa K. Manning, James Gauderman, Han Chen, Patricia B. Munroe, Dabeeru C. Rao, Diana van Heemst, Susan Redline, Raymond Noordam, Heming Wang
{"title":"A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations","authors":"Pavithra Nagarajan, Thomas W. Winkler, Amy R. Bentley, Clint L. Miller, Aldi T. Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R. Brown, John L. Morrison, Ayush Giri, Jeffrey R. O’Connell, Traci M. Bartz, Lisa de las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E. Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian’an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D. Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan van der Graaf, Peter J. van der Most, Yujie Wang, Stefan Weiss, Kenneth E. Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D. Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R. Attia, Lydia Bazzanno, Max A. Breyer, Jennifer A. Brody, Brian E. Cade, Hung-hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S. de Vries, Latchezar M. Dimitrov, Anh Do, Jiawen Du, Charles T. Dupont, Todd L. Edwards, Michele K. Evans, Tariq Faquih, Stephan B. Felix, Susan P. Fisher-Hoch, James S. Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G. Hairston, Anthony J. Hanley, Iris M. Heid, Sami Heikkinen, Heather M. Highland, Michelle M. Hood, Mika Kähönen, Carrie A. Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N. Kelly, Pirjo Komulainen, Daniel Levy, Henry J. Lin, Peter Y. Liu, Pedro Marques-Vidal, Joseph B. McCormick, Hao Mei, James B. Meigs, Cristina Menni, Kisung Nam, Ilja M. Nolte, Natasha L. Pacheco, Lauren E. Petty, Hannah G. Polikowsky, Michael A. Province, Bruce M. Psaty, Laura M. Raffield, Olli T. Raitakari, Stephen S. Rich, Renata L. Riha, Lorenz Risch, Martin Risch, Edward A. Ruiz-Narvaez, Rodney J. Scott, Colleen M. Sitlani, Jennifer A. Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems van Dijk, Otis D. Wilson, Rui Xia, Jie Yao, Kristin L. Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E. Below, Carsten A. Böger, David Conen, Simon R. Cox, Marcus Dörr, Mary F. Feitosa, Ervin R. Fox, Nora Franceschini, Sina A. Gharib, Vilmundur Gudnason, Sioban D. Harlow, Jiang He, Elizabeth G. Holliday, Zoltan Kutalik, Timo A. Lakka, Deborah A. Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C. Morrison, Brenda WJH Penninx, Patricia A. Peyser, Jerome I. Rotter, Harold Snieder, Tim D. Spector, Lynne E. Wagenknecht, Nicholas J. Wareham, Alan B. Zonderman, Kari E. North, Myriam Fornage, Adriana M. Hung, Alisa K. Manning, James Gauderman, Han Chen, Patricia B. Munroe, Dabeeru C. Rao, Diana van Heemst, Susan Redline, Raymond Noordam, Heming Wang","doi":"10.1038/s41380-025-02954-w","DOIUrl":null,"url":null,"abstract":"<p>Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes’ functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.</p>","PeriodicalId":19008,"journal":{"name":"Molecular Psychiatry","volume":"24 1","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41380-025-02954-w","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes’ functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.
期刊介绍:
Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.