A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

IF 9.6 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Pavithra Nagarajan, Thomas W. Winkler, Amy R. Bentley, Clint L. Miller, Aldi T. Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R. Brown, John L. Morrison, Ayush Giri, Jeffrey R. O’Connell, Traci M. Bartz, Lisa de las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E. Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian’an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D. Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan van der Graaf, Peter J. van der Most, Yujie Wang, Stefan Weiss, Kenneth E. Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D. Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R. Attia, Lydia Bazzanno, Max A. Breyer, Jennifer A. Brody, Brian E. Cade, Hung-hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S. de Vries, Latchezar M. Dimitrov, Anh Do, Jiawen Du, Charles T. Dupont, Todd L. Edwards, Michele K. Evans, Tariq Faquih, Stephan B. Felix, Susan P. Fisher-Hoch, James S. Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G. Hairston, Anthony J. Hanley, Iris M. Heid, Sami Heikkinen, Heather M. Highland, Michelle M. Hood, Mika Kähönen, Carrie A. Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N. Kelly, Pirjo Komulainen, Daniel Levy, Henry J. Lin, Peter Y. Liu, Pedro Marques-Vidal, Joseph B. McCormick, Hao Mei, James B. Meigs, Cristina Menni, Kisung Nam, Ilja M. Nolte, Natasha L. Pacheco, Lauren E. Petty, Hannah G. Polikowsky, Michael A. Province, Bruce M. Psaty, Laura M. Raffield, Olli T. Raitakari, Stephen S. Rich, Renata L. Riha, Lorenz Risch, Martin Risch, Edward A. Ruiz-Narvaez, Rodney J. Scott, Colleen M. Sitlani, Jennifer A. Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems van Dijk, Otis D. Wilson, Rui Xia, Jie Yao, Kristin L. Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E. Below, Carsten A. Böger, David Conen, Simon R. Cox, Marcus Dörr, Mary F. Feitosa, Ervin R. Fox, Nora Franceschini, Sina A. Gharib, Vilmundur Gudnason, Sioban D. Harlow, Jiang He, Elizabeth G. Holliday, Zoltan Kutalik, Timo A. Lakka, Deborah A. Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C. Morrison, Brenda WJH Penninx, Patricia A. Peyser, Jerome I. Rotter, Harold Snieder, Tim D. Spector, Lynne E. Wagenknecht, Nicholas J. Wareham, Alan B. Zonderman, Kari E. North, Myriam Fornage, Adriana M. Hung, Alisa K. Manning, James Gauderman, Han Chen, Patricia B. Munroe, Dabeeru C. Rao, Diana van Heemst, Susan Redline, Raymond Noordam, Heming Wang
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引用次数: 0

Abstract

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes’ functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.

Abstract Image

对来自不同人群的 811 405 人的血压基因与睡眠时间相互作用的大规模全基因组研究
虽然短睡眠时间和长睡眠时间都与高血压风险升高有关,但我们对它们与控制血压的生物途径的相互作用的理解仍然有限。为了解决这个问题,我们对来自不同人群的811,405人进行了全基因组跨群体基因的短睡眠和长睡眠时间相互作用分析,分析了三个血压特征(收缩压、舒张压和脉压)。我们发现了22个新的血压基因-睡眠时间相互作用位点,映射到23个基因。研究这些基因的功能意义揭示了神经、甲状腺、骨代谢和造血途径,这需要未来研究适应睡眠健康生活方式的血压管理。短睡眠(12)和长睡眠(10)之间的相互作用不重叠,强调了两种极端睡眠时间对心血管健康的不同影响的似是而非的本质。我们的一些基因座针对特定的人群背景或性别,强调了在考虑精确医学设计血压管理方法时解决基因-环境相互作用中纠缠的异质性的重要性。
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来源期刊
Molecular Psychiatry
Molecular Psychiatry 医学-精神病学
CiteScore
20.50
自引率
4.50%
发文量
459
审稿时长
4-8 weeks
期刊介绍: Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
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