‘Complement-ing’ tissue inflammation via granzyme K?

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-04-04 DOI:10.1038/s41590-025-02120-y

Dimitrios C. Mastellos, John D. Lambris

引用次数: 0

Abstract

Distinct proteolytic pathways share convergent activation patterns in many pathological contexts. Two new studies in Nature report on how effector memory-like CD8+ T cells infiltrate inflamed tissues in various disease states and drive tissue-restricted complement activation via the release of granzyme K.

Abstract Image

查看原文本刊更多论文

“补充”组织炎症通过颗粒酶K？

在许多病理背景下，不同的蛋白水解途径共享趋同的激活模式。Nature上的两项新研究报告了效应记忆样CD8+ T细胞如何在各种疾病状态下浸润炎症组织，并通过释放颗粒酶K来驱动组织限制性补体激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.