IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis (Adv. Sci. 13/2025)

Abstract

Insulin-Regulated Aminopeptidase

In septic platelets, insulin-regulated aminopeptidase (IRAP) adsorbs ribosomal proteins and cooperates with autophagosomal proteins to promote lysosomal degradation of r-proteins, thereby providing amino acids required for durative glycolysis, which ensures mitochondrial function and finally provides abundant ATP for prolonged platelet activation. In addition, IRAP is also involved in SNARE complex assembly to facilitate granules release. More details can be found in article number 2411914 by Jinghong Zhao, Junping Wang, Shilei Chen, and co-workers.