Metabolic Engineering of Corynebacterium glutamicum for High-Level Production of 1,5-Pentanediol, a C5 Diol Platform Chemical (Adv. Sci. 13/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-03 DOI:10.1002/advs.202570090

Yu Jung Sohn, Se-Yeun Hwang, Haeyoung Lee, Subeen Jeon, Ji Young Park, Jaehyung Kim, Donghyuk Kim, Ki Jun Jeong, Sang Yup Lee, Jeong Chan Joo, Jin-Byung Park, Si Jae Park

引用次数: 0

Abstract

Metabolic Engineering of Corynebacterium glutamicum

In article number 2412670, Jeong Chan Joo, Jin-Byung Park, Si Jae Park, and co-workers highlight the development of a metabolically engineered Corynebacterium glutamicum for sustainable production of 1,5-pentanediol via a lysine-derived pathway. Through systems metabolic engineering strategies, the final strain produced 43.4 gL⁻¹ 1,5-pentanediol, showcasing systematic approaches to biobased chemical synthesis by microbial cell factories.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.