Cyclic Diphenylchloronium-Salt-Triggered Coupling of Sulfides with Nucleophiles: Modular Assembly of Pharmaceuticals

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-02 DOI:10.1021/acs.orglett.5c00768

Bangxiong Kang, Li Wei, Huanfeng Jiang, Chaorong Qi

引用次数: 0

Abstract

We report a novel coupling strategy enabled by cyclic diphenylchloronium salt that facilitates reactions between sulfides and diverse nucleophiles, including oxygen- and nitrogen-based species. The methodology efficiently produces structurally varied valuable compounds, including carbamates, carboxylic esters, aryl ethers, and alkylated amines, under mild, operationally simple conditions. The protocol’s synthetic utility was highlighted through modular preparation of five important drugs and five structural analogues, demonstrating significant potential for drug discovery applications.

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环二苯氯盐引发的硫化物与亲核试剂的偶联：药物的模块化组装

我们报告了一种新的偶联策略，由环二苯氯铵盐激活，促进硫化物和多种亲核试剂（包括氧基和氮基物质）之间的反应。该方法在温和、操作简单的条件下有效地生产出结构多样的有价值化合物，包括氨基甲酸酯、羧酸酯、芳醚和烷基化胺。通过模块化制备五种重要药物和五种结构类似物，突出了该方案的合成效用，显示出药物发现应用的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.