Photocatalytic Radical Cascade Cyclization of N-(o-Cyanobiaryl)acrylamides with Sulfonyl Chlorides

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-04-02 DOI:10.1021/acs.joc.5c00288

Mei-Jin Gao, Jian-Hong Fan, Yu Liu

引用次数: 0

Abstract

A photoredox-catalyzed radical cascade cyclization of N-(o-cyanobiaryl)acrylamides with sulfonyl chlorides for the construction of sulfonyl-containing pyrido[4,3,2-gh]phenanthridines has been disclosed. The developed synthetic tool tolerates a broad range of sulfonyl chlorides to undergo a cascade sequence, including sulfonyl radical addition, nitrile insertion, and cyclization.

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N-（o-氰芳基）丙烯酰胺与磺酰氯的光催化自由基级联环化

报道了一种光氧化催化N-(o- cyanobiaryyl)丙烯酰胺与磺酰氯的自由基级联环化反应，用于构造含磺酰吡啶[4,3,2-gh]菲菲啶。该合成工具可耐受多种磺酰氯化物的级联反应，包括磺酰自由基加成、腈插入和环化。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.