The clones have STRACK: Tracing responses to leukemic mutations

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-04-03 DOI:10.1016/j.stem.2025.03.001

Eirini P. Papapetrou

引用次数: 0

Abstract

Rodriguez-Fraticelli and colleagues combine genetic barcoding with ex vivo expansion and sister-cell analysis of murine hematopoietic stem cells (HSCs) carrying inducible leukemia driver mutations. This approach allows them to capture the intrinsic heterogeneity of clonal cell behaviors and study how these impact cell fates upon acquisition of leukemia driver mutations.

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克隆具有STRACK：追踪对白血病突变的反应

Rodriguez-Fraticelli及其同事将基因条形码与体外扩增和携带可诱导白血病驱动突变的小鼠造血干细胞（hsc）的姊妹细胞分析结合起来。这种方法使他们能够捕捉到克隆细胞行为的内在异质性，并研究这些异质性在获得白血病驱动突变时如何影响细胞命运。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.