Effect and mechanism of GLP-1 on cognitive function in diabetes mellitus.

IF 3.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Neuroscience Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.3389/fnins.2025.1537898

Xiaoke Dou, Lei Zhao, Jing Li, Yaqiu Jiang

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引用次数: 0

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder associated with cognitive impairment. Glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) have shown neuroprotective effects.

Scope of review: This review explores the impact of DM on cognitive function. Diabetes-related cognitive impairment is divided into three stages: diabetes-associated cognitive decrements, mild cognitive impairment (MCI), and dementia. GLP-1R agonists (GLP-1RAs) have many functions, such as neuroprotection, inhibiting infection, and metabolic regulation, and show good application prospects in improving cognitive function. The mechanisms of GLP-1RAs neuroprotection may be interconnected, warranting further investigation. Understanding these mechanisms could lead to targeted treatments for diabetes-related cognitive dysfunction.

Major conclusions: Therefore, this paper reviewed the regulatory effects of GLP-1 on cognitive dysfunction and its possible mechanism. Further research is required to fully explore the potential of GLP-1 and its analogs in this context.

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GLP-1对糖尿病认知功能的影响及机制。

背景：糖尿病（DM）是一种与认知障碍相关的代谢性疾病。胰高血糖素样肽-1（GLP-1）及其受体（GLP-1R）具有神经保护作用：本综述探讨了糖尿病对认知功能的影响。糖尿病相关认知功能损害分为三个阶段：糖尿病相关认知功能减退、轻度认知功能损害（MCI）和痴呆。GLP-1R 激动剂（GLP-1RAs）具有神经保护、抑制感染、调节代谢等多种功能，在改善认知功能方面具有良好的应用前景。GLP-1RAs 的神经保护机制可能相互关联，值得进一步研究。了解这些机制可为糖尿病相关认知功能障碍的靶向治疗提供依据：因此，本文综述了 GLP-1 对认知功能障碍的调节作用及其可能的机制。要充分挖掘 GLP-1 及其类似物在这方面的潜力，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroscience NEUROSCIENCES-

CiteScore

6.20

自引率

4.70%

发文量

2070

审稿时长

14 weeks

期刊介绍： Neural Technology is devoted to the convergence between neurobiology and quantum-, nano- and micro-sciences. In our vision, this interdisciplinary approach should go beyond the technological development of sophisticated methods and should contribute in generating a genuine change in our discipline.