First reported case of a spontaneous and healthy pregnancy in a woman with persistent CAR T-cells 5 years after treatment for diffuse large B-cell lymphoma.

IF 10.3 1区 医学 Q1 IMMUNOLOGY
Ethan Abraham Canty, Lori Broderick, Daniel Flaherty, Marin Xavier, Sunita D Nasta, Lina Dajani, Andrew A White
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引用次数: 0

Abstract

Chimeric antigen receptor T-cell (CAR T-cell) therapy has significantly advanced cancer treatments and remission rates; however, questions exist regarding the impacts on both fertility and immune effects on infants born to mothers who have undergone CAR T-cell therapy. There are no known reported cases of persistence of CAR T-cells after cancer therapy in pregnancy. Here, we present a case of a woman with relapsed refractory diffuse large B-cell lymphoma who undertook an experimental CAR T-cell therapy, had persistence of CAR T-cells 5 years after achieving remission, spontaneously became pregnant and delivered a healthy male infant. Our case provides an example of a healthy pregnancy despite the persistence of CAR T-cells and the resultant healthy newborn without evidence of immunologic or other health effects from the CAR T-cells.

首例报道的漫漫性大b细胞淋巴瘤治疗5年后CAR - t细胞持续存在的妇女自然健康怀孕的病例。
嵌合抗原受体t细胞(CAR - t细胞)疗法显著提高了癌症治疗和缓解率;然而,对于接受CAR - t细胞治疗的母亲所生婴儿的生育能力和免疫效果的影响存在疑问。目前还没有关于CAR - t细胞在妊娠期接受癌症治疗后持续存在的报道。在这里,我们报告了一例复发的难治性弥漫性大b细胞淋巴瘤的女性,她接受了实验性CAR - t细胞治疗,在缓解后持续使用CAR - t细胞5年,自然怀孕并生下了一个健康的男婴。我们的病例提供了一个健康怀孕的例子,尽管CAR - t细胞持续存在,并且由此产生的健康新生儿没有证据表明CAR - t细胞对免疫或其他健康产生影响。
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来源期刊
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
17.70
自引率
4.60%
发文量
522
审稿时长
18 weeks
期刊介绍: The Journal for ImmunoTherapy of Cancer (JITC) is a peer-reviewed publication that promotes scientific exchange and deepens knowledge in the constantly evolving fields of tumor immunology and cancer immunotherapy. With an open access format, JITC encourages widespread access to its findings. The journal covers a wide range of topics, spanning from basic science to translational and clinical research. Key areas of interest include tumor-host interactions, the intricate tumor microenvironment, animal models, the identification of predictive and prognostic immune biomarkers, groundbreaking pharmaceutical and cellular therapies, innovative vaccines, combination immune-based treatments, and the study of immune-related toxicity.
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