Multistage Linear Frequency Scanning Mass Analysis Processed by Fractional Fourier Transform.

IF 3.1 2区 化学 Q2 BIOCHEMICAL RESEARCH METHODS
Haoqiang Yan, Liangshun Hu, Shi Zhang, Dayu Li, Wei Xu
{"title":"Multistage Linear Frequency Scanning Mass Analysis Processed by Fractional Fourier Transform.","authors":"Haoqiang Yan, Liangshun Hu, Shi Zhang, Dayu Li, Wei Xu","doi":"10.1021/jasms.5c00012","DOIUrl":null,"url":null,"abstract":"<p><p>The common method of mass analysis in a linear ion trap mass spectrometer is to eject ions with different mass-to-charge ratios (<i>m</i>/<i>z</i>) at different times by resonance excitation. Ions are ejected onto an electron multiplier (EM), generating pulsed signals called the ejection signal. Typically, the ejection signal consisting of multiple pulses is smoothed into a wider Gaussian-like pulse due to the limited bandwidth of the electronic system. For different scan rates and different samples, this bandwidth-limited electronic system and signal smoothing process will differentially increase the peak width and thus decrease the mass resolution. In this study, experiments at different scan rates were performed on a \"Brick\" miniature linear ion trap mass spectrometer. We propose a multistage linear frequency scanning mode that achieves improved mass resolution and extended mass range, in which fractional Fourier transform is applied to process the ejection signals. The proposed signal processing method improves the mass resolution and mitigates the impact of ghost peaks attributed to scattered ion ejection. A peak width of 0.84 Da at a <i>m</i>/<i>z</i> value of 242 and a scan rate of 8000 Da/s was achieved in experiments.</p>","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Society for Mass Spectrometry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/jasms.5c00012","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

Abstract

The common method of mass analysis in a linear ion trap mass spectrometer is to eject ions with different mass-to-charge ratios (m/z) at different times by resonance excitation. Ions are ejected onto an electron multiplier (EM), generating pulsed signals called the ejection signal. Typically, the ejection signal consisting of multiple pulses is smoothed into a wider Gaussian-like pulse due to the limited bandwidth of the electronic system. For different scan rates and different samples, this bandwidth-limited electronic system and signal smoothing process will differentially increase the peak width and thus decrease the mass resolution. In this study, experiments at different scan rates were performed on a "Brick" miniature linear ion trap mass spectrometer. We propose a multistage linear frequency scanning mode that achieves improved mass resolution and extended mass range, in which fractional Fourier transform is applied to process the ejection signals. The proposed signal processing method improves the mass resolution and mitigates the impact of ghost peaks attributed to scattered ion ejection. A peak width of 0.84 Da at a m/z value of 242 and a scan rate of 8000 Da/s was achieved in experiments.

分数阶傅里叶变换处理的多级线性频率扫描质量分析。
线性离子阱质谱仪进行质量分析的常用方法是通过共振激发在不同时间喷射具有不同质荷比(m/z)的离子。离子被喷射到电子倍增器(EM)上,产生脉冲信号,称为喷射信号。通常,由于电子系统的带宽有限,由多个脉冲组成的弹射信号被平滑成一个更宽的类高斯脉冲。对于不同的扫描速率和不同的样品,这种带宽有限的电子系统和信号平滑过程会不同地增加峰宽,从而降低质量分辨率。本研究在“Brick”微型线性离子阱质谱仪上进行了不同扫描速率的实验。我们提出了一种多级线性频率扫描模式,该模式采用分数阶傅里叶变换对弹射信号进行处理,从而提高了质量分辨率和扩展了质量范围。所提出的信号处理方法提高了质量分辨率,减轻了分散离子喷射引起的幽灵峰的影响。实验结果表明,在m/z值为242时,扫描峰宽为0.84 Da,扫描速率为8000 Da/s。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
5.50
自引率
9.40%
发文量
257
审稿时长
1 months
期刊介绍: The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信