Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-04-02 DOI:10.1126/sciadv.adr5541

Shan Zuo, Yanhua Li, Yushi Chen, Gangwei Jiang, Zhixuan Zhou, Tian-Bing Ren, Lanlan Chen, Sulai Liu, Shulin Huang, Xiao-Bing Zhang, Lin Yuan

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Abstract

Accurate differentiation of benign and malignant breast tumors is paramount for establishing schemes of breast cancer treatment and prognosis. Here we report a near-infrared (NIR) fluorescence probe (YF-1) with the overexpressed cathepsin C (CTSC) in metastatic breast tumors as the detecting substrate. This probe allows accurate identification of malignant tumor tissue specimens among tumor tissue specimens with unknown properties in a blind study. Importantly, a series of visible to NIR CTSC-activated fluorescence probes based on the same strategy realize effective identification of malignant tumor tissues, suggesting that CTSC could be the specific identification substrate of malignant breast tumors. Furthermore, a hydrophilic PEG moiety is coupled into YF-1, producing another CTSC-activated NIR probe (YF-2). YF-2 has excellent tumor-targeting capability, enabling the visualization of lung-metastatic breast tumors. The excellent detection accuracy and construction versatility of CTSC probes pave the way for preoperative diagnosis of malignant breast tumors.

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通过对转移相关生物标志物的准确影像分析，对乳腺恶性肿瘤进行快速分类和辅助评价

准确鉴别乳腺良恶性肿瘤对制定乳腺癌治疗方案和预后至关重要。在这里，我们报告了一种近红外（NIR）荧光探针（YF-1），以转移性乳腺肿瘤中过表达的组织蛋白酶C （CTSC）作为检测底物。该探针可在盲法研究中，在性质未知的肿瘤组织标本中准确识别恶性肿瘤组织标本。重要的是，基于相同策略的一系列可见到近红外的CTSC激活荧光探针实现了对恶性肿瘤组织的有效识别，提示CTSC可能是乳腺恶性肿瘤的特异性鉴定底物。此外，亲水性PEG片段偶联到YF-1中，产生另一个ctsc激活的近红外探针（YF-2）。YF-2具有出色的肿瘤靶向能力，可实现肺转移性乳腺肿瘤的可视化。CTSC探针优良的检测精度和结构通用性为乳腺恶性肿瘤的术前诊断奠定了基础。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.