Current opinions invited review: testosterone and transgender medicine.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Current Opinion in Endocrinology & Diabetes and Obesity Pub Date : 2025-04-02 DOI:10.1097/MED.0000000000000912

Jinghang Luo, Rita Upreti

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引用次数: 0

Abstract

Purpose of review: Transgender individuals have a gender identity incongruent with their sex assigned at birth. Social, medical and surgical methods are often affirming. This review focuses on updates from the last 18 months mainly in testosterone use in masculinising gender-affirming hormone therapy (GAHT) in postpubertal adults, and also antiandrogens for suppression or blockade of endogenous testosterone in feminising GAHT. Mental and sexual healthcare are vital for many transgender patients, but are not the focus of this review.

Recent findings: There has been a considerable increase in publications regarding testosterone GAHT in recent years, though narrative reviews, opinion pieces and case series continue to dominate. There has also been a notable increase in prospective studies and valuable data particularly from large longitudinal cohorts and studies aiming to refine GAHT prescribing and better understand long-term effects on aspects such as fertility, cardiometabolic and bone health as well as adverse effects.

Summary: Testosterone GAHT is life changing. Increased research will help GAHT optimisation, and improve understanding of tissue-specific impacts and long-term safety. Longer-term data, prospective studies and utilisation of novel research tools and approaches are needed to enrich our understanding and prescribing of testosterone and its blockers in GAHT.

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审查目的：变性人的性别认同与其出生时的性别不一致。社会、医疗和手术方法通常是肯定性的。本综述重点关注过去 18 个月中的最新进展，主要是在青春期后成年人的男性化性别确认激素疗法（GAHT）中使用睾酮，以及在女性化性别确认激素疗法中使用抗雄激素抑制或阻断内源性睾酮。心理和性保健对许多变性患者至关重要，但不是本综述的重点：近年来，有关睾酮性GAHT的出版物大幅增加，但仍以叙述性综述、观点文章和系列病例为主。前瞻性研究和有价值的数据也显著增加，特别是来自大型纵向队列和研究的数据，这些研究旨在完善 GAHT 的处方，更好地了解其对生育、心脏代谢和骨骼健康等方面的长期影响以及不良反应。加强研究将有助于优化 GAHT，提高对特定组织影响和长期安全性的认识。我们需要更长期的数据、前瞻性研究以及利用新型研究工具和方法来丰富我们对睾酮及其阻断剂在 GAHT 中的应用的理解和处方。

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来源期刊

Current Opinion in Endocrinology & Diabetes and Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

5.80

自引率

3.10%

发文量

128

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Endocrinology, Diabetes and Obesity delivers a broad-based perspective on the most recent and exciting developments in the field from across the world. Published bimonthly and featuring twelve key topics – including androgens, gastrointestinal hormones, diabetes and the endocrine pancreas, and neuroendocrinology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.