An update on the role and mechanisms of periodontitis in cardiovascular diseases

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-03-29 DOI:10.1016/j.cellsig.2025.111770

Yuping Lai , Sibo Liu , Chenxin Song , Ting Long , Li Song , Meixiu Jiang

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Abstract

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Despite extensive studies into the causes and therapies for CVDs, their incidence and prevalence continue to increase. Periodontitis is a multifactorial, chronic inflammatory disease related to systemic health. Current research suggests that periodontitis may be an unconventional risk factor for CVDs and it may increase the risk of CVDs such as atherosclerosis, coronary heart disease, myocardial infarction, hypertension, heart failure as well as cardiomyopathy. For all these reasons, it is quite plausible that prevention of periodontitis has an impact on the onset or progression of CVDs. Therefore, in this review, we investigated the association between periodontitis caused by oral microorganisms and different CVDs. In addition, we discuss the various mechanisms by which periodontitis contributes to the onset and progression of CVDs. Our review aims to raise global awareness of periodontitis, particularly its role in CVDs, provide a basis for the prevention and treatment of CVDs and offer potential therapeutic targets

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牙周炎在心血管疾病中的作用和机制的最新进展。

心血管疾病（cvd）是世界范围内死亡的主要原因。尽管对心血管疾病的病因和治疗进行了广泛的研究，但其发病率和流行率仍在继续增加。牙周炎是一种与全身健康相关的多因素慢性炎症性疾病。目前的研究表明，牙周炎可能是心血管疾病的一个非常规危险因素，它可能增加心血管疾病的风险，如动脉粥样硬化、冠心病、心肌梗死、高血压、心力衰竭和心肌病。由于所有这些原因，预防牙周炎对心血管疾病的发生或进展有影响是相当合理的。因此，在这篇综述中，我们研究了口腔微生物引起的牙周炎与不同cvd的关系。此外，我们还讨论了牙周炎导致心血管疾病发生和发展的各种机制。我们的综述旨在提高全球对牙周炎的认识，特别是其在心血管疾病中的作用，为心血管疾病的预防和治疗提供基础，并提供潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.