Stable dispersion and prolonged dissolution of hydrophilic pharmaceutical achieved by room-temperature atmospheric pressure atomic layer deposition.

Abstract

We demonstrate atomic layer deposition of SiO₂ films on hydrophilic diclofenac sodium pharmaceutical powder under ambient conditions. We reveal that the SiO₂ layer not only prolongs the dissolution but also enhances the surface zeta potential of the coated products, preventing sedimentation and enabling a highly stable dispersion in water.