Cover Feature: Oxidative Coupling of Guanidines and Isocyanides Catalyzed by Nickel(II): Access to Imidazoline Derivatives with Antibacterial Activity (ChemMedChem 7/2025)

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-04-01 DOI:10.1002/cmdc.202580704

Georgii A. Gavrilov, Tuan K. Nguyen, Dr. Svetlana A. Katkova, Dr. Nikolai V. Rostovskii, Dr. Elizaveta V. Rogacheva, Dr. Liudmila A. Kraeva, Dr. Mikhail A. Kinzhalov

引用次数: 0

Abstract

Isis, the ancient Egyptian goddess of health and the secrets of nature, is used symbolically on the cover. Isis appears as the creator of unique imidazoles. On their head rests the crown with a nickel disk rising between the horns, symbolizing the transition metal catalysis, while the feathers are embroidered with isocyanide essential for this transition. These compounds, demonstrate potent antibacterial activity and, continuing her mission of healing, may become the key to combating the growing threat of bacterial resistance. More details can be found in article 10.1002/cmdc.202400904 by Mikhail A. Kinzhalov and co-workers.

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封面专题：镍催化的胍类和异氰酸酯的氧化偶联（II）：获得具有抗菌活性的咪唑啉衍生物（ChemMedChem 7/2025）

封面上象征性地使用了古埃及的健康和自然秘密女神伊希斯。伊希斯作为独特的咪唑的创造者出现。在它们的头上有一顶王冠，在角之间有一个镍盘，象征着过渡金属的催化作用，而羽毛上则绣着这种过渡所必需的异氰化物。这些化合物，显示出强大的抗菌活性，并继续她的愈合使命，可能成为对抗细菌耐药性日益增长的威胁的关键。更多细节可以在10.1002/cmdc中找到。202400904, Mikhail A. Kinzhalov及其同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.