Regioselective Nickel-Catalyzed Hydrotrifluoroalkylation of Alkynes to Construct Trisubstituted Allylic Trifluoromethyl Alkenes

Abstract

Introducing fluorine atoms or fluorine-containing groups into drug molecules has become a common approach in drug design, with the incorporation of trifluoromethyl groups as a focal point of research in the field of organic fluorochemistry. Here, we describe a nickel-catalyzed hydrotrifluoromethylation of internal alkynes with trifluoromethyl alkyl bromides to synthesize a series of highly regioselective trifluoromethyl allyl trisubstituted alkenes. This reaction is characterized by mild conditions and broad functional-group tolerance, providing an efficient and practical approach to synthesize trifluoromethyl allyl trisubstituted alkenes.