Ten-membered lactones with antifungal activity against the postharvest pathogens from Penicillium restrictum

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-03-28 DOI:10.1016/j.fitote.2025.106495

Jing Sun , Feng-Shuang Wei , Tong-De Zhao , Rong-Fei Ma , Xiao-Xiao Hu , Heng-Xiang Li , Chao Liu , Ju-Cheng Zhang , Xue-Qiong Yang , Ya-Bin Yang , Zhong-Tao Ding

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引用次数: 0

Abstract

Two undescribed ten-membered lactones, named penicirestricols A (1) and B (2), and two unprecedented ten-membered lactone-adenine hybrids, penicirestricols C (3) and D (4), along with four known compounds, decarestrictines B (5), A₁ (6), F (7), and I (8) were isolated from the endophytic fungus Penicillium restrictum. The structures were determined by 1D, 2D NMR techniques, mass spectrometry, ECD, and NMR calculations. Compounds 3, 7, and 8 from P. restrictum showed significant antifungal activities against postharvest pathogens Fusarium asiaticum and Alternaria tenuissima with MICs ≤8 μg/mL. Thus, the compounds isolated from P. restrictum have the potentiality to be developed as the novel antifungal agents.

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对限制青霉采后病原菌具有抗真菌活性的十元内酯

从内生真菌Penicillium restrictum中分离出两种未被描述的十元内酯，命名为penicirestricols A(1)和B(2)，以及两种前所未有的十元内酯-腺嘌呤杂交产物penicirestricols C(3)和D(4)，以及四种已知化合物decarestrictiines B(5)、A1(6)、F(7)和I(8)。通过1D， 2D NMR技术，质谱，ECD和NMR计算确定结构。其中化合物3、7、8对采后病原菌亚洲镰刀菌（Fusarium asiatium）和纹枯病镰刀菌（Alternaria tenuissima）具有显著的抗真菌活性，mic≤8 μg/mL。因此，从限制草中分离得到的化合物具有开发新型抗真菌药物的潜力。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.