Hemoglobin catalyzed oxidative cyanation of tertiary amines in water

IF 4.7 2区化学 Q2 CHEMISTRY, PHYSICAL

Applied Catalysis A: General Pub Date : 2025-03-28 DOI:10.1016/j.apcata.2025.120248

Wenning Song , Xiaoxuan Chen , Wenbo Kan , Yuming Piao , Chunyu Wang , Lei Wang , Fengxi Li , Peng Chen , Zhi Wang

引用次数: 0

Abstract

We reported the oxidative cyanation of tertiary amines catalyzed by hemoglobin derived from rabbit blood (HbRb). Using water as the solvent and tert-butyl hydroperoxide (TBHP) as the oxidant, with a loading of 0.06 % mmol HbRb and ethyl cyanoformate (ECF) as the cyanide source, the oxidative cyanation was successfully catalyzed, yielding corresponding products in excellent yields ranging from 71 % to 93 % at room temperature. This strategy demonstrates high efficiency, employs mild reaction conditions, utilizes a safe cyanide source, and exhibits a broad substrate scope, thereby highlighting its valuable potential in non-natural oxidative reactions.

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来源期刊

Applied Catalysis A: General 化学-环境科学

CiteScore

9.00

自引率

5.50%

发文量

415

审稿时长

24 days

期刊介绍： Applied Catalysis A: General publishes original papers on all aspects of catalysis of basic and practical interest to chemical scientists in both industrial and academic fields, with an emphasis onnew understanding of catalysts and catalytic reactions, new catalytic materials, new techniques, and new processes, especially those that have potential practical implications. Papers that report results of a thorough study or optimization of systems or processes that are well understood, widely studied, or minor variations of known ones are discouraged. Authors should include statements in a separate section "Justification for Publication" of how the manuscript fits the scope of the journal in the cover letter to the editors. Submissions without such justification will be rejected without review.