Total Synthesis of Pegaharmine I Enabled by Visible‐Light Photocatalytic Nitrone Formation

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-03-29 DOI:10.1002/ejoc.202500245

Manikanta Swami Pothana, Huang-Chieh Lu, Bor-Cherng Hong, Su-Ying Chien

引用次数: 0

Abstract

The first total synthesis of pegaharmine I was accomplished by a three‐step strategy featuring a visible‐light‐photocatalyzed nitrone formation reaction as the key step. The structure of this natural product was confirmed by crystallographic analysis. Water‐promoted photocatalysis, achieved by incorporating water into the reaction medium, has also been established.

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以可见光光催化的腈酮形成反应为关键步骤，通过三步策略首次完成了pegaharmine I 的全合成。这种天然产物的结构通过晶体学分析得到了证实。此外，还通过在反应介质中加入水实现了水促进光催化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.