A digital citizen science intervention to reduce HIV stigma and promote HIV testing: a randomized clinical trial among adolescents and young adults in Kazakhstan.
Alissa Davis, Laura Nyblade, Yihang Sun, Olga Balabekova, Sara E Landers, Denis Gryazev, Joseph D Tucker, Valera Gulyaev, Susan L Rosenthal, Karsten Lunze, Weiming Tang, Azamat Kuskulov, Assel Terlikbayeva, Sholpan Primbetova, Mingway Chang, Alfiya Y Denebayeva, Aikerim Utegulovna Akhmetova, Ainur Absemetova, Sholpan Karzhaubayeva, Sairankul Kassymbekova, Marina Maximova, Zhannat Mussina, Gulnar Bekenova, Zhamilya Nugmanova, Zhanna Kalmatayeva, Ludmila Polyakova, Zhanneta Kanaevna Zhazykbaeva, Vitaliy Vinogradov, Amir Shaikezhanov, Meruyert Darisheva, Bella Orynbetova, Elena Norakidze, Mashirov Kozhakhmet, Akbota Tolegenova, Aknur Imadillda, Dariga Satkhozhina, Alikhan Kartamyssov, Zhamilya Kanieva, Albina Aleshina, Olzhas Makhan, Aida Muravyova, Adema Rahimzanova, Arman Duisenbayev, Zhanerke Tursynbek, Nurgazy Dias, Malika Beken, Miras Murzakhan, Zhandos Ali Brown, Daniyal Maitekov, Artur Li, Sandizaira Mergen, Dautali Mergenov, Amirali Kuanysh, Anuar Rakhimbekov, Yenlik Baisbay, Alibek Aruzhan, Zhasmina Kozhambet, Denis Grebenchishikov, Dmitriy Bekker, Sultan Kozhamberdiev, Dauren Salykov, Madina Sagimbayeva, Kamila Yussupova, Gaukhar Mergenova
{"title":"A digital citizen science intervention to reduce HIV stigma and promote HIV testing: a randomized clinical trial among adolescents and young adults in Kazakhstan.","authors":"Alissa Davis, Laura Nyblade, Yihang Sun, Olga Balabekova, Sara E Landers, Denis Gryazev, Joseph D Tucker, Valera Gulyaev, Susan L Rosenthal, Karsten Lunze, Weiming Tang, Azamat Kuskulov, Assel Terlikbayeva, Sholpan Primbetova, Mingway Chang, Alfiya Y Denebayeva, Aikerim Utegulovna Akhmetova, Ainur Absemetova, Sholpan Karzhaubayeva, Sairankul Kassymbekova, Marina Maximova, Zhannat Mussina, Gulnar Bekenova, Zhamilya Nugmanova, Zhanna Kalmatayeva, Ludmila Polyakova, Zhanneta Kanaevna Zhazykbaeva, Vitaliy Vinogradov, Amir Shaikezhanov, Meruyert Darisheva, Bella Orynbetova, Elena Norakidze, Mashirov Kozhakhmet, Akbota Tolegenova, Aknur Imadillda, Dariga Satkhozhina, Alikhan Kartamyssov, Zhamilya Kanieva, Albina Aleshina, Olzhas Makhan, Aida Muravyova, Adema Rahimzanova, Arman Duisenbayev, Zhanerke Tursynbek, Nurgazy Dias, Malika Beken, Miras Murzakhan, Zhandos Ali Brown, Daniyal Maitekov, Artur Li, Sandizaira Mergen, Dautali Mergenov, Amirali Kuanysh, Anuar Rakhimbekov, Yenlik Baisbay, Alibek Aruzhan, Zhasmina Kozhambet, Denis Grebenchishikov, Dmitriy Bekker, Sultan Kozhamberdiev, Dauren Salykov, Madina Sagimbayeva, Kamila Yussupova, Gaukhar Mergenova","doi":"10.1071/SH24235","DOIUrl":null,"url":null,"abstract":"<p><p>Background Kazakhstan has a high HIV incidence among adolescents and young adults (AYA), and high HIV stigma contributing to low HIV testing uptake. We examined whether an AYA-developed digital crowdsourced intervention reduced HIV stigma compared with conventional public health materials among AYA in Almaty, Kazakhstan. Methods A total of 216 AYA (females:116/males:110) aged 16-24 years were recruited to the online study cohort and randomized 1:1 to the intervention or control arm. AYA were exposed to the crowdsourced intervention or control materials once a week for 5weeks, with equivalent exposures between arms. Outcomes included a total HIV stigma score assessed at baseline, immediately post-intervention and 2months post-intervention from January to August 2023. We conducted multilevel mixed models to compare changes over time by arm and sex. Results AYA in the intervention arm had significantly lower HIV testing stigma 2months post-intervention (adjusted mean change (AMC): -0.73 (-1.07, -0.39)) than AYA in the control arm (AMC: -0.06 (-0.42, 0.30); P =0.032). Female AYA in the intervention arm had significantly lower total HIV stigma immediately post-intervention (AMC: -4.91 (-7.25, -2.58)) and 2months post-intervention (AMC: -5.16 (-7.48, -2.84)) than females in the control arm (immediately post-intervention AMC: -0.03 (-2.63, 2.57) and 2-months post-intervention AMC: -0.07 (-2.70, 2.56); P =0.012, P =0.012). Conclusions The AYA-developed crowdsourced intervention decreased HIV testing stigma, although this effect was moderated by sex, and decreased total HIV stigma among female AYA. Crowdsourced interventions may be a promising way to engage communities to develop interventions to decrease HIV stigma.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sexual health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1071/SH24235","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Background Kazakhstan has a high HIV incidence among adolescents and young adults (AYA), and high HIV stigma contributing to low HIV testing uptake. We examined whether an AYA-developed digital crowdsourced intervention reduced HIV stigma compared with conventional public health materials among AYA in Almaty, Kazakhstan. Methods A total of 216 AYA (females:116/males:110) aged 16-24 years were recruited to the online study cohort and randomized 1:1 to the intervention or control arm. AYA were exposed to the crowdsourced intervention or control materials once a week for 5weeks, with equivalent exposures between arms. Outcomes included a total HIV stigma score assessed at baseline, immediately post-intervention and 2months post-intervention from January to August 2023. We conducted multilevel mixed models to compare changes over time by arm and sex. Results AYA in the intervention arm had significantly lower HIV testing stigma 2months post-intervention (adjusted mean change (AMC): -0.73 (-1.07, -0.39)) than AYA in the control arm (AMC: -0.06 (-0.42, 0.30); P =0.032). Female AYA in the intervention arm had significantly lower total HIV stigma immediately post-intervention (AMC: -4.91 (-7.25, -2.58)) and 2months post-intervention (AMC: -5.16 (-7.48, -2.84)) than females in the control arm (immediately post-intervention AMC: -0.03 (-2.63, 2.57) and 2-months post-intervention AMC: -0.07 (-2.70, 2.56); P =0.012, P =0.012). Conclusions The AYA-developed crowdsourced intervention decreased HIV testing stigma, although this effect was moderated by sex, and decreased total HIV stigma among female AYA. Crowdsourced interventions may be a promising way to engage communities to develop interventions to decrease HIV stigma.
期刊介绍:
Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence.
Officially sponsored by:
The Australasian Chapter of Sexual Health Medicine of RACP
Sexual Health Society of Queensland
Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.