Comparison of safety and efficacy of negative pressure aspiration assisted retrograde intrarenal surgery and traditional percutaneous nephrolithotomy in the treatment of upper urinary tract stones larger than 2cm: a systematic review and meta-analysis.

IF 12.5 2区 医学 Q1 SURGERY
Zhaoxin Ying, Shaoxiong Ming, Rui Yang, Bangyu Zou, Yiying Jia, Meng Shu, Ziyu Fang, Xiaofeng Gao
{"title":"Comparison of safety and efficacy of negative pressure aspiration assisted retrograde intrarenal surgery and traditional percutaneous nephrolithotomy in the treatment of upper urinary tract stones larger than 2cm: a systematic review and meta-analysis.","authors":"Zhaoxin Ying, Shaoxiong Ming, Rui Yang, Bangyu Zou, Yiying Jia, Meng Shu, Ziyu Fang, Xiaofeng Gao","doi":"10.1097/JS9.0000000000002363","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Percutaneous nephrolithotomy (PCNL) is widely regarded as the first-line treatment for upper urinary tract stones larger than 2 cm, as recommended by major urological associations. However, a growing body of research highlights the safety and effectiveness of retrograde intrarenal surgery (RIRS) for managing stones of this size in the upper urinary tract, especially with the advent of suction-assisted techniques in RIRS. This study aims to systematically evaluate the safety and efficacy of negative pressure aspiration-assisted retrograde intrarenal surgery (NPAA-RIRS) in comparison to traditional PCNL.</p><p><strong>Method: </strong>Eligible studies were found by searching the PubMed, Embase, Web of Science and the CNKI databases for relevant reports published until July 2024. Outcome measures included initial and final stone-free rate (SFR), secondary operation, operation time, hemoglobin level reduction, blood transfusion, interventional embolization, postoperative hospital stay, complications. The assessment of publication bias was conducted using a funnel plot. Ten studies from nine articles were included, involving 1,259 patients.</p><p><strong>Results: </strong>NPAA-RIRS group showed lower hemoglobin level reduction (WMD = - 1.31, 95% CI [-1.64, - 0.99], P < 0.001), less blood transfusion (RR = 0.15, 95% CI [0.05, 0.50], P = 0.002), shorter postoperative hospital stay (WMD: - 1.93, 95% CI [-2.54, - 1.32], P < 0.001), lower Clavien-Dindo I-II complication rate (RR: 0.51, 95% CI [0.38, 0.67], P < 0.001), and lower overall complication rate (RR = 0.52, 95% CI [0.40, 0.68], P < 0.001) compared to the PCNL group. The PCNL group had shorter operation time (WMD = 0.68, 95% CI [0.22, 1.13], P = 0.003), higher initial SFR (RR = 0.87, 95% CI [0.83, 0.92], P < 0.001), and lower rate of secondary operation (RR = 2.51, 95% CI [1.52, 4.12], P < 0.001) compared to the NPAA-RIRS group. There were no statistically significant differences between the two groups in interventional embolization (RR = 0.28, 95% CI [0.06, 1.33], P = 0.11), final SFR (RR = 0.98, 95% CI [0.94, 1.01], P = 0.740), and Clavien-Dindo III-IV complication rate (RR: 0.65, 95% CI [0.28, 1.51], P = 0.316).</p><p><strong>Conclusion: </strong>For upper urinary tract stones larger than 2 cm, both NPAA-RIRS and PCNL are equally safe and effective, achieving comparable final SFR. NPAA-RIRS offers advantages in terms of reduced complications, whereas PCNL shows benefits in shorter operation times and a lower likelihood of requiring secondary procedures. Clinicians can therefore select the most suitable approach based on individual patient circumstances.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/JS9.0000000000002363","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Percutaneous nephrolithotomy (PCNL) is widely regarded as the first-line treatment for upper urinary tract stones larger than 2 cm, as recommended by major urological associations. However, a growing body of research highlights the safety and effectiveness of retrograde intrarenal surgery (RIRS) for managing stones of this size in the upper urinary tract, especially with the advent of suction-assisted techniques in RIRS. This study aims to systematically evaluate the safety and efficacy of negative pressure aspiration-assisted retrograde intrarenal surgery (NPAA-RIRS) in comparison to traditional PCNL.

Method: Eligible studies were found by searching the PubMed, Embase, Web of Science and the CNKI databases for relevant reports published until July 2024. Outcome measures included initial and final stone-free rate (SFR), secondary operation, operation time, hemoglobin level reduction, blood transfusion, interventional embolization, postoperative hospital stay, complications. The assessment of publication bias was conducted using a funnel plot. Ten studies from nine articles were included, involving 1,259 patients.

Results: NPAA-RIRS group showed lower hemoglobin level reduction (WMD = - 1.31, 95% CI [-1.64, - 0.99], P < 0.001), less blood transfusion (RR = 0.15, 95% CI [0.05, 0.50], P = 0.002), shorter postoperative hospital stay (WMD: - 1.93, 95% CI [-2.54, - 1.32], P < 0.001), lower Clavien-Dindo I-II complication rate (RR: 0.51, 95% CI [0.38, 0.67], P < 0.001), and lower overall complication rate (RR = 0.52, 95% CI [0.40, 0.68], P < 0.001) compared to the PCNL group. The PCNL group had shorter operation time (WMD = 0.68, 95% CI [0.22, 1.13], P = 0.003), higher initial SFR (RR = 0.87, 95% CI [0.83, 0.92], P < 0.001), and lower rate of secondary operation (RR = 2.51, 95% CI [1.52, 4.12], P < 0.001) compared to the NPAA-RIRS group. There were no statistically significant differences between the two groups in interventional embolization (RR = 0.28, 95% CI [0.06, 1.33], P = 0.11), final SFR (RR = 0.98, 95% CI [0.94, 1.01], P = 0.740), and Clavien-Dindo III-IV complication rate (RR: 0.65, 95% CI [0.28, 1.51], P = 0.316).

Conclusion: For upper urinary tract stones larger than 2 cm, both NPAA-RIRS and PCNL are equally safe and effective, achieving comparable final SFR. NPAA-RIRS offers advantages in terms of reduced complications, whereas PCNL shows benefits in shorter operation times and a lower likelihood of requiring secondary procedures. Clinicians can therefore select the most suitable approach based on individual patient circumstances.

负压吸引辅助逆行肾内手术与传统经皮肾镜取石术治疗大于2厘米的上尿路结石的安全性和有效性比较:系统综述和荟萃分析。
背景:经皮肾镜取石术(PCNL)被广泛认为是治疗大于2cm的上尿路结石的一线治疗方法,并被主要泌尿学协会推荐。然而,越来越多的研究强调逆行肾内手术(RIRS)治疗上尿路结石的安全性和有效性,特别是在RIRS中引入了吸引辅助技术。本研究旨在系统评价负压吸入辅助逆行肾内手术(NPAA-RIRS)与传统PCNL的安全性和有效性。方法:通过检索PubMed、Embase、Web of Science和CNKI数据库,检索截止到2024年7月已发表的相关报道,找到符合条件的研究。观察指标包括初始和最终结石清除率(SFR)、二次手术、手术时间、血红蛋白水平降低、输血、介入栓塞、术后住院时间、并发症。采用漏斗图对发表偏倚进行评估。纳入了来自9篇文章的10项研究,涉及1259名患者。结果:NPAA-RIRS组显示低血红蛋白水平降低(大规模杀伤性武器= - 1.31,95%可信区间(-1.64,- 0.99),P < 0.001),减少输血(RR = 0.15, 95%可信区间[0.05,0.50],P = 0.002),术后住院时间短(大规模杀伤性武器:- 1.93,95%可信区间(-2.54,- 1.32),P < 0.001),低Clavien-Dindo i ii并发症率(RR: 0.51, 95% CI [0.38, 0.67], P < 0.001),并降低总体并发症率(RR = 0.52, 95%可信区间[0.40,0.68],造廔组相比P < 0.001)。与NPAA-RIRS组相比,PCNL组手术时间较短(WMD = 0.68, 95% CI [0.22, 1.13], P = 0.003),初始SFR较高(RR = 0.87, 95% CI [0.83, 0.92], P < 0.001),二次手术率较低(RR = 2.51, 95% CI [1.52, 4.12], P < 0.001)。两组在介入栓塞(RR = 0.28, 95% CI [0.06, 1.33], P = 0.11)、最终SFR (RR = 0.98, 95% CI [0.94, 1.01], P = 0.740)、Clavien-Dindo III-IV并发症发生率(RR: 0.65, 95% CI [0.28, 1.51], P = 0.316)方面差异无统计学意义。结论:对于大于2 cm的上尿路结石,NPAA-RIRS和PCNL同样安全有效,最终SFR相当。NPAA-RIRS在减少并发症方面具有优势,而PCNL在更短的手术时间和更低的二次手术可能性方面具有优势。因此,临床医生可以根据个别患者的情况选择最合适的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信