Current Approaches for Assessments of Neutralizing, Binding, and Effector Functions of Antibodies on the Path to Antibody-Mediated Prevention Strategies for HIV-1.

IF 0.8 4区医学 Q4 IMMUNOLOGY

Current HIV Research Pub Date : 2025-03-27 DOI:10.2174/011570162X363301250314034023

David C Montefiori, Guido Ferrari, Dieter Mielke, LaTonya D Williams, Georgia D Tomaras

引用次数: 0

Abstract

Robust assay technologies and reference reagents are essential components in efforts to develop safe and effective antibody-mediated prevention strategies for HIV-1. Here, we de-scribe current approaches used to conduct standardized assessments of neutralizing, binding, and Fc receptor-mediated effector functions of vaccine-elicited antibodies, with an emphasis on recent developments that enable early precursors and intermediates of broadly neutralizing antibodies (bnAbs) to be monitored. We also describe how these assay technologies were adapted to facili-tate clinical evaluations of passively delivered bnAbs for HIV-1 prevention.

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在HIV-1抗体介导的预防策略的途径中，目前评估抗体的中和、结合和效应功能的方法。

强大的检测技术和参考试剂是开发安全有效的 HIV-1 抗体介导预防策略的重要组成部分。在此，我们阐述了目前用于对疫苗诱导抗体的中和、结合和 Fc 受体介导的效应功能进行标准化评估的方法，并重点介绍了可对广泛中和抗体（bnAbs）的早期前体和中间产物进行监测的最新进展。我们还介绍了如何对这些检测技术进行调整，以便对用于预防 HIV-1 的被动递送 bnAbs 进行临床评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.