Unlocking the Potential of ctDNA in Sarcomas: A Review of Recent Advances.

IF 4.5 2区 医学 Q1 ONCOLOGY
Cancers Pub Date : 2025-03-20 DOI:10.3390/cancers17061040
Sahana Aiyer, Tae-Hee Kim, Katharine Collier, Raphael Pollock, Claire Verschraegen, Daniel G Stover, Gabriel Tinoco
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引用次数: 0

Abstract

Soft tissue sarcomas (STSs) constitute a group of tumors with heterogeneous alterations and different biological behavior. Genetic profiling techniques have immense potential to revolutionize sarcoma classification, detection, and treatment. Cell-free DNA (cfDNA) analysis offers a minimally invasive approach to profiling tumor alterations, including tracking specific mutations or targeted panels of cancer-related genes via DNA sequencing methods. Circulating tumor DNA (ctDNA) platforms have gained popularity as a noninvasive alternative to tissue biopsies, offering a less invasive approach to tumor profiling. Nonetheless, ctDNA profiling in concordance with standard solid tumor comprehensive genomic profiling (CGP) is poorly characterized for STSs. Ultra-low-pass whole-genome sequencing and whole exome sequencing of cfDNA have yet to be fully leveraged in patients with sarcomas. This comprehensive review provides an overview of the application of ctDNA in STSs.

释放ctDNA在肉瘤中的潜力:最新进展综述。
软组织肉瘤(STSs)是一类具有异质性改变和不同生物学行为的肿瘤。基因图谱技术在肉瘤的分类、检测和治疗方面具有巨大的潜力。无细胞DNA (cfDNA)分析提供了一种微创方法来分析肿瘤变化,包括通过DNA测序方法跟踪特定突变或癌症相关基因的靶向组。循环肿瘤DNA (ctDNA)平台作为组织活检的一种非侵入性替代方法已经受到欢迎,为肿瘤分析提供了一种侵入性较小的方法。尽管如此,与标准实体肿瘤综合基因组图谱(CGP)一致的ctDNA图谱对STSs的表征很差。cfDNA的超低通全基因组测序和全外显子组测序尚未在肉瘤患者中得到充分利用。本文就ctDNA在STSs中的应用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancers
Cancers Medicine-Oncology
CiteScore
8.00
自引率
9.60%
发文量
5371
审稿时长
18.07 days
期刊介绍: Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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