Diterpenoids from the aril of Torreya grandis and their cytotoxicity

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-26 DOI:10.1016/j.tet.2025.134621

Jun-Ru Guo , Min-Jian Dong , Cheng-Xin Sun , Jun Dai , Mao-Sheng Zhang , Shi-Ji Xiao

引用次数: 0

Abstract

Three new diterpenoids (2, 3, and 5), two new natural products (1 and 7), along with three analogues were isolated from the aril of Torreya grandis. The structural elucidation of these compounds was achieved through detailed NMR analysis, and the absolute configurations were confirmed using ECD techniques. The NMR data of 8β,18-dihydroxy-9(11),13-abietadien-12-one (6) was revised. The cytotoxic effects of the isolated compounds on SW1990, A549, MDB-MA-231, and HCT116 cells were evaluated using the MTT assay.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.