Revisiting the association between REM sleep behavior disorder and Parkinson's disease progression.

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-03-19 DOI:10.1016/j.parkreldis.2025.107801

Xin-Tao Wu, Qiu-Han Xu

引用次数: 0

Abstract

This study challenges the assumption that REM sleep behavior disorder (RBD) is a marker of severe Parkinson's disease (PD) progression. Using two-sample Mendelian randomization, we found no causal link between PD progression and RBD. Interestingly, RBD exhibited a potential protective effect on motor and composite PD progression, warranting further investigation.

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.