{"title":"A case report of severe myocarditis combined with erythema multiforme caused by herpes simplex virus-1.","authors":"Anwu Huang, Bin Lin, Xiaojun Ji, Shanjiang Chen","doi":"10.3389/fcvm.2025.1421364","DOIUrl":null,"url":null,"abstract":"<p><p>Herpes simplex virus-1 (HSV-1) is a recognised pathogen that is primarily associated with skin mucosal infection. However, in rare cases, it has been observed to lead to skin extramucosal manifestations, including myocarditis. The present case report documents the occurrence of severe myocarditis in a 35-year-old female patient, attributed to HSV-1 infection. She received cardiac support in the form of VA-ECMO (Venoarterial Extracorporeal Membrane Oxygenation). Concurrently, the patient exhibited cutaneous manifestations of erythema multiforme, which demonstrated a favourable response to antiviral and hormonal therapy. This case underscores the significance of HSV-1 as a causative agent of myocarditis and underscores the necessity for vigilance and expeditious treatment of potential cardiac complications caused by HSV-1.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1421364"},"PeriodicalIF":2.8000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937124/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cardiovascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcvm.2025.1421364","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Herpes simplex virus-1 (HSV-1) is a recognised pathogen that is primarily associated with skin mucosal infection. However, in rare cases, it has been observed to lead to skin extramucosal manifestations, including myocarditis. The present case report documents the occurrence of severe myocarditis in a 35-year-old female patient, attributed to HSV-1 infection. She received cardiac support in the form of VA-ECMO (Venoarterial Extracorporeal Membrane Oxygenation). Concurrently, the patient exhibited cutaneous manifestations of erythema multiforme, which demonstrated a favourable response to antiviral and hormonal therapy. This case underscores the significance of HSV-1 as a causative agent of myocarditis and underscores the necessity for vigilance and expeditious treatment of potential cardiac complications caused by HSV-1.
期刊介绍：
Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers?
At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
