Enzalutamide in biochemically recurrent prostate cancer: key findings from the EMBARK study.

IF 3 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI:10.1080/14796694.2025.2479331

Neal D Shore, Henry H Woo

引用次数: 0

Abstract

This podcast features two of the investigators from the international, randomized, phase 3 EMBARK trial (NCT02319837) in conversation. EMBARK evaluated the efficacy and safety of enzalutamide plus androgen deprivation therapy and enzalutamide monotherapy, as compared with androgen deprivation therapy alone, in patients with nonmetastatic castration-sensitive prostate cancer and biochemical recurrence at high risk for metastasis. In this podcast, the second in the EMBARK series, the speakers discuss the key efficacy and safety findings from the trial, consider some of the patient-reported outcomes and their implications for quality of life, and review some of the implications for clinical practice.

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恩杂鲁胺在生化复发性前列腺癌中的作用：来自EMBARK研究的关键发现。

本播客以两名来自国际随机3期EMBARK试验（NCT02319837）的研究人员为特色。EMBARK评估了enzalutamide联合雄激素剥夺治疗和enzalutamide单药治疗在非转移性去势敏感前列腺癌和转移高风险生化复发患者中的疗效和安全性，并与单独雄激素剥夺治疗进行了比较。在本播客（EMBARK系列的第二期）中，演讲者讨论了该试验的主要疗效和安全性发现，考虑了一些患者报告的结果及其对生活质量的影响，并回顾了一些对临床实践的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.