{"title":"Cohort study suggests benefit of earlier initiation of clozapine","authors":"","doi":"10.1002/pu.31297","DOIUrl":null,"url":null,"abstract":"<p>A population-based cohort study has found that among patients with first-episode schizophrenia who experienced a relapse, continuation of the same treatment or switching to a non-clozapine antipsychotic was not as effective as switching to clozapine in preventing a second relapse. The results call into question the recommendation in treatment guidelines to use clozapine only as third-line treatment. Study results were published in the February 2025 issue of <i>Lancet Psychiatry</i>.</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31297","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A population-based cohort study has found that among patients with first-episode schizophrenia who experienced a relapse, continuation of the same treatment or switching to a non-clozapine antipsychotic was not as effective as switching to clozapine in preventing a second relapse. The results call into question the recommendation in treatment guidelines to use clozapine only as third-line treatment. Study results were published in the February 2025 issue of Lancet Psychiatry.
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