{"title":"Marine Carotenoids: Unlocking Advanced Antioxidant Mechanisms and Therapeutic Applications for Oxidative Stress.","authors":"Fatima Iftikhar Shah, Hassan Imran, Fatima Akram, Tooba Khalid, Somia Shehzadi","doi":"10.1007/s12033-025-01420-w","DOIUrl":null,"url":null,"abstract":"<p><p>Marine ecosystems are a rich source of bioactive compounds, with carotenoids like astaxanthin, fucoxanthin, and zeaxanthin demonstrating significant antioxidant properties. These carotenoids neutralize reactive oxygen species (ROS), protecting against oxidative damage. This review examines their molecular structures, biosynthesis pathways, and mechanisms of action, including radical scavenging and involvement in key signaling pathways. Antioxidant assays confirm their potent ability to mitigate oxidative stress, with therapeutic implications for chronic diseases such as cancer, cardiovascular disorders, neurodegenerative diseases, and diabetes. Carotenoids also show promise in food, cosmetic, and nutraceutical applications, emphasizing the importance of sustainable sourcing. This review highlights the role of carotenoids in preventive health strategies and their potential to address oxidative stress-related diseases.</p>","PeriodicalId":18865,"journal":{"name":"Molecular Biotechnology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biotechnology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12033-025-01420-w","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Marine ecosystems are a rich source of bioactive compounds, with carotenoids like astaxanthin, fucoxanthin, and zeaxanthin demonstrating significant antioxidant properties. These carotenoids neutralize reactive oxygen species (ROS), protecting against oxidative damage. This review examines their molecular structures, biosynthesis pathways, and mechanisms of action, including radical scavenging and involvement in key signaling pathways. Antioxidant assays confirm their potent ability to mitigate oxidative stress, with therapeutic implications for chronic diseases such as cancer, cardiovascular disorders, neurodegenerative diseases, and diabetes. Carotenoids also show promise in food, cosmetic, and nutraceutical applications, emphasizing the importance of sustainable sourcing. This review highlights the role of carotenoids in preventive health strategies and their potential to address oxidative stress-related diseases.
期刊介绍：
Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.
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