{"title":"Dual faces of itaconate and its derivatives: exploring diverse biological functions in immunity and infectious diseases.","authors":"Cecilie Poulsen, Dominic G Roy, David Olagnier","doi":"10.1093/hmg/ddae177","DOIUrl":null,"url":null,"abstract":"<p><p>The intersection of immunology and infectious diseases has been revolutionized by the emergence of immunometabolism, highlighting the critical role of metabolic processes in regulating immune responses. In recent years, itaconate alongside its derivatives dimethyl-itaconate (DMI) and 4-octyl-itaconate (4-OI), have received attention for their potent immunomodulatory and antimicrobial properties. This review examines the unique roles of itaconate and its derivatives in modulating immune functions and their implications in infectious diseases. We also explore their structural and functional discrepancies. Notably, while itaconate generally exhibits anti-inflammatory and antimicrobial effects, its derivatives may operate through distinct mechanisms, often exhibiting enhanced electrophilic properties. This review of recent research underscores the potential of itaconate and its derivatives as therapeutic agents, paving the way for future clinical applications in managing inflammation and infectious diseases.</p>","PeriodicalId":13070,"journal":{"name":"Human molecular genetics","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human molecular genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/hmg/ddae177","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The intersection of immunology and infectious diseases has been revolutionized by the emergence of immunometabolism, highlighting the critical role of metabolic processes in regulating immune responses. In recent years, itaconate alongside its derivatives dimethyl-itaconate (DMI) and 4-octyl-itaconate (4-OI), have received attention for their potent immunomodulatory and antimicrobial properties. This review examines the unique roles of itaconate and its derivatives in modulating immune functions and their implications in infectious diseases. We also explore their structural and functional discrepancies. Notably, while itaconate generally exhibits anti-inflammatory and antimicrobial effects, its derivatives may operate through distinct mechanisms, often exhibiting enhanced electrophilic properties. This review of recent research underscores the potential of itaconate and its derivatives as therapeutic agents, paving the way for future clinical applications in managing inflammation and infectious diseases.
期刊介绍：
Human Molecular Genetics concentrates on full-length research papers covering a wide range of topics in all aspects of human molecular genetics. These include:
the molecular basis of human genetic disease
developmental genetics
cancer genetics
neurogenetics
chromosome and genome structure and function
therapy of genetic disease
stem cells in human genetic disease and therapy, including the application of iPS cells
genome-wide association studies
mouse and other models of human diseases
functional genomics
computational genomics
In addition, the journal also publishes research on other model systems for the analysis of genes, especially when there is an obvious relevance to human genetics.
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