Knowledge, attitudes, and practices toward biologics among systemic lupus erythematosus patients: a cross-sectional study.

IF 3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Frontiers in Public Health Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI:10.3389/fpubh.2025.1445576

Xue Xu, Mengru Du, Peng Lai, Zhiling Zhao, Linyu Geng, Jun Liang, Haifeng Chen, Lingyun Sun

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Abstract

Objective: This study aimed to investigate the knowledge, attitudes, and practices (KAP) toward biologics among systemic lupus erythematosus (SLE) patients.

Methods: A cross-sectional study was conducted at Nanjing Drum Tower Hospital from March 2023 to January 2024. Demographic information and KAP were obtained through the distribution of self-designed questionnaires.

Results: A total of 543 SLE patients participated in this study, with a mean age of 39.14 ± 13.08 years. The mean scores for knowledge, attitude, and practice were 6.08 ± 5.49 (possible range: 0-32), 33.14 ± 4.01 (possible range: 10-50), and 12.06 ± 3.95 (possible range: 6-30), respectively. Multivariate logistic regression analysis revealed that knowledge score (OR = 1.08, 95% CI: 1.019-1.144, p = 0.009), attitude score (OR = 1.476, 95% CI: 1.337-1.63, p < 0.001), average monthly income of 5,000-10,000 Yuan (OR = 2.129, 95% CI: 1.327-3.416, p = 0.002), and average monthly income of more than 10,000 Yuan (OR = 2.245, 95% CI: 1.184-4.260, p = 0.013) were independently associated with proactive practice. Structural equation modeling revealed significant direct effects of knowledge on attitude (β = 0.586, p < 0.001) and practice (β = 0.140, p = 0.041). Additionally, attitudes were found to directly influence practice (β = 0.628, p < 0.001).

Conclusion: SLE patients demonstrated inadequate knowledge, suboptimal attitudes, and passive practices regarding biologics. It is recommended that healthcare providers prioritize education and interventions aimed at enhancing knowledge, fostering positive attitudes, and promoting proactive practices regarding biologic therapies among SLE patients.

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.