Green and Efficient One-Pot Synthesis of 1,3-Diaryl-3-arylamino-propan-1-one Derivatives Using Thiamine Hydrochloride as a Catalyst

Abstract

In this efficient approach, thiamine hydrochloride serves as an organocatalyst for the rapid synthesis of 1,3-diaryl-3-arylamino-propan-1-ones via a one-pot, multicomponent reaction (MCR). This protocol enables the production of β-amino carbonyl compounds using acetophenones with various substituted aromatic amines and aromatic aldehydes via a Mannich condensation reaction. The method offers several advantages, such as adhering to sustainable practices, following green chemistry principles, and providing an easy work-up process, yielding 1,3-diaryl-3-arylamino-propan-1-ones in moderate to excellent quantities.