The Cells of the Vasculature: Advances in the Regulation of Vascular Tone in the Brain and Periphery

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Luke S. Dunaway, William A. Mills III, Ukpong B. Eyo, Brant E. Isakson
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引用次数: 0

Abstract

The vasculature is a complex tissue in which multiple cell types coordinate the regulation of tissue perfusion in response to hemodynamic and biochemical signals. Advances in this field are continuing to deepen our understanding of the relative importance of these cell types through the body. In the peripheral vasculature, tone is generated primarily by smooth muscle cells and regulated by endothelial cells, and neurons. In the brain parenchyma, unique cell types including pericytes, perivascular astrocytes and microglia, also contribute to the regulation of arterial and capillary tone. Here, we provide a cell-by-cell review of the regulation of vascular tone and highlight recent advances in the regulation of vascular tone in both the periphery and cerebral vasculature.

Abstract Image

血管细胞:脑和外周血管张力调节的研究进展
血管系统是一个复杂的组织,多种细胞类型协调组织灌注的调节,以响应血流动力学和生化信号。这一领域的进展正在继续加深我们对这些细胞类型在人体中的相对重要性的理解。在外周血管系统中,张力主要由平滑肌细胞产生,并受内皮细胞和神经元调节。在脑实质中,包括周细胞、血管周围星形胶质细胞和小胶质细胞在内的独特细胞类型也有助于动脉和毛细血管张力的调节。在这里,我们对血管张力的调节进行了逐个细胞的回顾,并重点介绍了外周血管和脑血管血管张力调节的最新进展。
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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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