Targeted Delivery of c(RGDfk)-Modified Liposomes to Bone Marrow Through In Vivo Hitchhiking Neutrophils for Multiple Myeloma Therapy (Adv. Sci. 12/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-03-27 DOI:10.1002/advs.202570079

Huiwen Liu, Bo Zhang, Hongrui Chen, Honglan Wang, Xifeng Qin, Chunyan Sun, Zhiqing Pang, Yu Hu

引用次数: 0

Abstract

Targeted Drug Delivery to the Bone Marrow

In article number 2409895, Liu Huiwen, Zhiqing Pang, Yu Hu, and co-workers introduce an innovative bone marrow-targeting strategy that utilizes c(RGDfk)-modified liposomes as therapeutic carriers. These liposomes (the cargo) exploit aging neutrophils (the purple cells), known for their intrinsic ability to home to the bone marrow, as natural transport vehicles. This approach outperformed conventional drug delivery systems by enhancing precision and minimizing off-target effects.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.