Microwave-Assisted Facile Synthesis of 1,2-Benzisoxazoles, Isoxazoloquinolines, and Isothiazoloquinolines in [BMIM(SO2Cl)][OTs] Ionic Liquid as a Recyclable System

Abstract

A green method of the synthesis of 1,2-benzisoxazole, isoxazolo- and isothiazolo-quinoline from 2-hydroxyaryl ketoximes in the presence of [BMIM(SO₂Cl)][OTs] ionic liquid has been demonstrated under microwave irradiation. The noticeable advantages of this method over other reported methods are less reaction time, simple work-up procedure and excellent yields (85–96%). The method also highlights the reuse and recycle of ionic liquid employed (up to four cycles) with negligible loss of yield.