PD-1/PD-L1 checkpoint inhibitor-induced encephalitis in patients with lung adenocarcinoma: a report of three cases.

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL

Oxford Medical Case Reports Pub Date : 2025-03-20 eCollection Date: 2025-03-01 DOI:10.1093/omcr/omae201

Takayo Ota, Masaaki Terashima, Yukihiro Hamada, Shuichi Ueno, Shigeru Kawai, Noriko Tanaka, Kaoru Matsui, Noriyuki Masuda

引用次数: 0

Abstract

Immune checkpoint inhibitor (ICI)-induced encephalitis is rare. We present three cases of encephalitis associated with ICIs in lung adenocarcinoma patients. These patients presented with a variety of symptoms, but one of the common symptoms for all patients was loss of consciousness. All patients responded well to steroid treatment and survived longer than one month after the onset of symptoms. These cases highlight the difficulties in diagnosing encephalitis based only on clinical information, and timely management is important to improve survival. Opportunistic infections also have to be ruled out to diagnose ICI-induced encephalitis especially when brain metastases co-exist.

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肺腺癌患者PD-1/PD-L1检查点抑制剂诱导脑炎：附3例报告

免疫检查点抑制剂（ICI）引起的脑炎是罕见的。我们报告了三例脑炎与肺腺癌患者的ICIs相关。这些患者表现出多种症状，但所有患者的共同症状之一是意识丧失。所有患者对类固醇治疗反应良好，并在症状出现后存活超过一个月。这些病例突出了仅根据临床信息诊断脑炎的困难，及时处理对提高生存率很重要。在诊断ici引起的脑炎时也必须排除机会性感染，特别是当脑转移共存时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oxford Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

发文量

125

审稿时长

19 weeks

期刊介绍： Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.