How Advanced Is Nanomedicine for Atherosclerosis?

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S508757

Xiang Gu, Lixin Du, Ruifang Lin, Zehui Ding, Zhihua Guo, Jiaming Wei, Ya Li

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引用次数: 0

Abstract

Advances in nanotechnology have opened new avenues for precision therapy, personalized medicine, and multifunctional theranostics in atherosclerosis (AS). This review provides a comprehensive overview of the role of nanoparticles (NPs) in precision medicine for AS, discussing their applications, challenges, and future prospects. The review first analyzes the current treatment landscape of AS and outlines potential biological targets for therapy. Various nanocarriers, including organic, inorganic, and hybrid systems, are evaluated for their therapeutic potential, with a focus on targeted drug delivery, anti-inflammatory therapy, vascular repair, plaque stabilization, and lipid clearance. Additionally, the review explores NP preparation methods, emphasizing strategies to enhance drug loading, stability, and controlled release. Finally, the translational challenges of NP-based therapies, including biocompatibility, large-scale production, regulatory hurdles, and clinical implementation, are critically analyzed. Future directions highlight the importance of interdisciplinary collaboration and technological innovation in advancing nanoparticle-based precision medicine for AS.

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纳米药物治疗动脉粥样硬化有多先进？

纳米技术的进步为动脉粥样硬化（AS）的精确治疗、个性化治疗和多功能治疗开辟了新的途径。本文综述了纳米颗粒（NPs）在AS精准医疗中的作用，讨论了它们的应用、挑战和未来前景。本文首先分析了目前AS的治疗前景，并概述了治疗的潜在生物学靶点。各种纳米载体，包括有机、无机和混合系统，评估其治疗潜力，重点是靶向药物输送、抗炎治疗、血管修复、斑块稳定和脂质清除。此外，本文还探讨了NP的制备方法，强调了提高药物负荷、稳定性和控释的策略。最后，对基于np疗法的转化挑战进行了批判性分析，包括生物相容性、大规模生产、监管障碍和临床实施。未来的方向突出了跨学科合作和技术创新在推进基于纳米颗粒的AS精准医学中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.