Prognostic gene expression profile of colorectal cancer

IF 2.6 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2025-03-22 DOI:10.1016/j.gene.2025.149433

Mohamed J. Saadh , Omer Qutaiba B. Allela , Radhwan Abdul Kareem , Lalji Baldaniya , Suhas Ballal , Raghav Vashishth , Manisha Parmar , Hayder Naji Sameer , Atheer Khdyair Hamad , Zainab H. Athab , Mohaned Adil

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Abstract

Colorectal cancer is a major global health burden, with significant heterogeneity in clinical outcomes among patients. Identifying robust prognostic gene expression signatures can help stratify patients, guide treatment decisions, and improve clinical management. This review provides an overview of current prognostic gene expression profiles in colorectal cancer research. We have synthesized evidence from numerous published studies investigating the association between tumor gene expression patterns and patient survival outcomes. The reviewed literature reveals several promising gene signatures that have demonstrated the ability to predict disease-free survival and overall survival in CRC patients, independent of standard clinicopathological risk factors. These genes are crucial in fundamental biological processes, including cell cycle control, epithelial-mesenchymal transition, and immune regulation. The implementation of prognostic gene expression tests in clinical practice holds great potential for enabling more personalized management strategies for colorectal cancer.

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结直肠癌预后基因表达谱。

结直肠癌是全球主要的健康负担，患者的临床结果存在显著的异质性。识别稳健的预后基因表达特征可以帮助患者分层，指导治疗决策，并改善临床管理。本文综述了目前在结直肠癌研究中的预后基因表达谱。我们从大量已发表的研究中综合了肿瘤基因表达模式与患者生存结果之间关系的证据。综述的文献揭示了几个有希望的基因特征，这些特征已经证明了预测结直肠癌患者无病生存和总生存的能力，独立于标准的临床病理危险因素。这些基因在细胞周期控制、上皮-间质转化和免疫调节等基本生物学过程中起着至关重要的作用。在临床实践中实施预后基因表达测试对于实现更个性化的结直肠癌管理策略具有巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.