Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity

Abstract

Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3–6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC₅₀ values.