Breaking the Mould: How the First Structure of a Deer Prion Suggests the Framework for Interspecies Strain Diversity and Transmission Barriers

IF 4.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Neurochemistry Pub Date : 2025-03-25 DOI:10.1111/jnc.70050

Szymon W. Manka

引用次数: 0

Abstract

Our Insight into the Structural Diversity of Prions Has Been Limited by Studies Focused on Rodent-Adapted Sheep (Scrapie) Prion Strains, Until Now. In a Recent Paper (Alam et al. 2024), the Caughey Research Group Presents the First Prion Structure from a Naturally Occurring Chronic Wasting Disease (CWD), Offering a Fresh Perspective.

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打破常规：鹿朊病毒的第一个结构如何提示种间菌株多样性和传播障碍的框架

到目前为止，我们对朊病毒结构多样性的了解仅限于对啮齿动物适应羊（痒病）朊病毒株的研究。在最近的一篇论文（Alam et al. 2024）中，Caughey研究小组提出了来自自然发生的慢性消耗性疾病（CWD）的第一个朊病毒结构，提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurochemistry 医学-神经科学

CiteScore

9.30

自引率

2.10%

发文量

181

审稿时长

2.2 months

期刊介绍： Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.